- A water-soluble, enzyme co-factor present in minute amounts in every living cell.
- It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.
MECHANISM OF ACTION:-
- Biotin deficiency associated with pregnancy
- Hair loss
- Brittle nails
- Skin rash in infants (seborrheic dermatitis)
- Mild depression
- Biotin is necessary for the proper functioning of enzymes that transport carboxyl units and fix carbon dioxide, and is required for various metabolic functions, including gluconeogenesis, lipogenesis, fatty acid biosynthesis, propionate metabolism, and catabolism of branched-chain amino acids.
- Skin rashes
- Digestive upset
- Infants (0 to 12 months) :7mcg
- Children(1 to 3 years) : 8mcg
- (4 to 8 years) : 12mcg
- (9 to 13 years) : 20mcg
- (14 to 18 years) : 25mcg
- Pregnant women:30mcg
- Breastfeeding women:35mcg
- Hypersensitivity to biotin or any of its components.
- In children, or pregnant or breastfeeding women without the physician’s advice.
WARNINGS AND PRECAUTIONS:-
- Smoking should be avoided as it may increase the metabolism of biotin in the body.
- Patients who undergo dialysis may require high dose which should be evaluated by the medical specialist.